why do we have an immune system
Since people and animals routinely get sick, it is obvious that our immune system (which includes but isn't limited to antibodies) doesn't always protect against pathogens. There are many reasons for this, far too many to summarize here, but one common reason is that it takes several days for the adaptive part of the immune system (which includes antibodies, among other things) to gear up and control an infection. Therefore, early treatment with antibiotics can help limit an infection before the immune system is fully engaged. Pathogenic bacteria are often resistant to immunity in many ways as well; that's one of the adaptations that makes them pathogenic. That means that even later in an infection, antibiotics can supplement the immune response and help eliminate bacteria. Note that many antibiotics require a functional immune system to be completely effective.
First, I want to note that ddiez has a good answer, but I thought this was good question to have a more expanded answer on immunology and pathogenesis. The First thing we need to establish what is a. The most common cold is, but the second place holder is a little harder to define. For example, has been shown to be nearly ubiquitous by. I actually disagree with the Wiki article on the common cold which puts (plural, which is not clear in the article) in second place.
For example, if you take look at, you can find that RSV and influenza are the more common. Now this does select for those who were sick enough to seek hospital treatment, but if you look at a recent more conducted through health clinics, you will again find coronavirus in much lower showing: [Editorial note, if someone wants to take the time to MathJax that table in, please go ahead. It seemed too large to insert the table as text. ] Thus, a cold is an infection from any of the above viruses, with a common cold likely being HRV or RSV. But how the body reacts to each of those is different. Secondly, how do we mount an immune response to a cold? There are two different kinds of immune responses in humans: or. (to not get to technical, you can come up with responses outside of these). Both responses are excitingly complex, and needed to fight a cold. The innate immune system is designed to handle the initial reactions to the pathogens, but often the adaptive immune system is what "clears" (viral clearance being the removal of the infection) the infection totally. In a novel infection, the adaptive immune system takes a, which is why a cold can last for a few days to two weeks.
This is when you get producing enough antibody to clear the infection. Then the next time you are infected by something of the same you will have a reservoir of cells already primed to make an immune response, and it will happen quicker. At least that is what the human body is trying to do. Viruses are trying to "evade" the immune system and proliferate (acknowledging of course that is a personification of viruses, and that they are not "trying" to do anything). The key word in the adaptive response is "novel. " If the pathogen is different enough, that is the are different enough, then the immune system won't recognize it. This is the principal strategy used by HRV. Depending on who you ask there are between 96-120 serotypes of HRV, so using a number of about 100 seems reasonable (120 is a much more recent number and the increase has largely correlated with better diagnostic tools). There don't seem to be additional stereotypes developing/mutating quickly (though conceivably they could), so as opposed to being infected by a mutated version of the cold you had last year, you're getting a different strain/serotype that was already in circulation. Thus if you got a different HRV infection once a year, you have about 100 years of rihno viruses colds (when you actually get that old you have senescence problems in the immune system).
RSV is a different story. You don't mount a (Table 10. 6. Fields Virology ; 6th Edition. LWW 2013) In fact, I know a researcher who would infect his lab members with the exact same strain of RSV every 6 months for years (before people would stop such a thing. ). Why RSV doesn't elicit lasting immunity--and in fact notably shorter immunity--is the subject of current research. As you can see in Table 10. 6, are generally not as long lasting as systemic infections. This can make sense from a macro viewБthe mucus successfully prevented the pathogen from spreading to the rest of the tissues in the body, so it's not as critical to respond to. On a more specific level we know that more is produced and the can be. But RSV seems specifically reduced. One leading idea is that two of the proteins produced by the virus, NS1 and NS2, cause an immune response to not be properly mounted. In other words, the virus is making materials that deliberately interfere with adaptive immune response. that just came out addresses this idea for a possible vaccine candidate.
- Views: 146
why do we get sick when its cold
why do some vaccinations require booster injections
why is there no cure for a cold
why do you get a runny nose with a cold
why is my liver function test high
why is aids a syndrome and not a disease
why do you cough when you eat ice cream