why is cancer considered a genetic disease

Despite decades of research, cancer continues to be a major cause of death in the United States. The disease is traditionally treated by a combination of surgery, radiation, and chemotherapy, which can have severe side effects. Recent advances in cancer biology have led to the development of targeted drugs as new and effective treatment options for some types of cancer. Dr. Charles Sawyers presents an overview of cancer biology and describes how understanding the molecular mechanisms involved in a type of cancer, chronic myeloid leukemia, resulted in the development of Gleevec, one of the first targeted cancer drugs.
What causes cancer?


All cancers are caused by changes to materials in our bodies called Б. Б When genes are damaged, they can develop changes called Б. Б Over time, damage can accummulate in cells, causing them to grow out of control and cause cancer. Read more about causes of cancer. How does cancer develop? It takes more than one gene mutation for cancer to occur. For most people who develop cancer, the cancer-causing gene mutations happen over the course of a lifetime, leading to cancer later in life.


Some people are born with a gene mutation that they inherited from their mother or father. This damaged gene puts them at higher risk for cancer than most people. When cancer occurs because of an inherited gene mutation, it is referred to as. different than other cancer? Cancers that occur because of an inherited mutation are called hereditary cancers. Cancers that are not due to an inherited gene change are called Бsporadic cancer. Б Sporadic cancer and differ in several ways, which are outlined.


What are the signs of hereditary cancers? There may be signs that point to an inherited mutation within a family. Sometimes the signs are as simple as a single family member being diagnosed with a certain type of cancer. Other signs require looking more closely at many family members across several generations to pick up certain patterns of cancer. Different gene mutations can cause different types of cancer. Read more about the signs of hereditary breast, ovarian, and related cancers (also known as ). Read more about signs of other types of.

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