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why do some antidepressants cause weight gain

Other antidepressants have been associated with less weight gain as a side effect. These antidepressants include:
(Lexapro, Cipralex), an SSRI duloxetine ( ), another SSRI buproprion (, Forfivo, and Aplenzin), an atypical antidepressant (Serzone), a serotonin antagonist and reuptake inhibitor (Effexor) and venlafaxine ER (Effexor XR), which are both serotonin-norepinephrine reuptake inhibitors (SNRIs) desvenlafaxine ( ), an SNRI (Fetzima), another SNRI (Viibryd), a serotonergic antidepressant (Trintellix), an atypical antidepressant (Emsam), a newer MAOI that you apply to your skin, which may lead to fewer side effects than MAOIs taken by mouth sertraline ( fluoxetine ( Some antidepressants may even cause weight loss.


For example, duloxetine and bupropion have been reported to lead to a fair amount weight loss in some people. Clinicians usually only prescribe tricyclic antidepressants after other drugs have failed to relieve depression. Tricyclic antidepressants help keep more serotonin and norepinephrine available to your brain.


These chemicals are made naturally by your body and are thought to affect your mood. By keeping more of them available to your brain, tricyclic antidepressants help elevate your mood. Some tricyclic antidepressants are also used to treat other conditions, mostly in off-label uses. These conditions include obsessive compulsive disorder (OCD) and chronic bedwetting. In lower doses, cyclic antidepressants are used to prevent migraines and to treat chronic pain. They are also sometimes used to help people with panic disorder.


Tricyclic antidepressants treat depression, but they have other effects on your body as well. They can affect automatic muscle movement for certain functions of the body, including secretions and digestion. They also block the effects of histamine, a chemical found throughout your body. Blocking histamine can cause effects such as drowsiness, blurred vision, dry mouth, constipation, and glaucoma. These may help explain some of the more troublesome side effects associated with these drugs.

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